FGFR4

FGFR4
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 4QQ5, 4QQC, 4QQJ, 4QQT, 4QRC, 4R6V, 4TYE, 4TYG, 4TYI, 4TYJ, 4UXQ, 4XCU
Identifikatori
Aliasi	FGFR4
Vanjski ID-jevi	OMIM: 134935 MGI: 95525 HomoloGene: 20461 GeneCards: FGFR4
Lokacija gena (čovjek) Hrom. Hromosom 5 (čovjek)[1] Bend 5q35.2 Početak 177,086,905 bp[1] Kraj 177,098,144 bp[1]
Lokacija gena (miš) Hrom. Hromosom 13 (miš)[2] Bend 13 B1|13 29.8 cM Početak 55,300,453 bp[2] Kraj 55,316,572 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • aktivnost sa transferazom • nucleotide binding • protein kinase activity • heparin binding • kinase activity • GO:0001948, GO:0016582 vezivanje za proteine • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity • fibroblast growth factor binding • fibroblast growth factor-activated receptor activity • ATP binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase activity • Receptorska tirozin-kinaza • transmembrane signaling receptor activity Ćelijska komponenta • integral component of membrane • endozom • Golđijev aparat • membrana • cell-cell junction • ćelijska membrana • integral component of plasma membrane • transport vesicle • extracellular region • Endoplazmatski retikulum • citoplazma • receptor complex Biološki proces • glucose homeostasis • Fosforilacija • phosphate ion homeostasis • response to bile acid • regulation of extracellular matrix disassembly • MAPK cascade • regulation of bile acid biosynthetic process • fibroblast growth factor receptor signaling pathway • regulation of lipid metabolic process • protein phosphorylation • GO:1901313 positive regulation of gene expression • positive regulation of cell population proliferation • positive regulation of DNA biosynthetic process • positive regulation of ERK1 and ERK2 cascade • positive regulation of proteolysis • protein autophosphorylation • peptidyl-tyrosine phosphorylation • Ćelijska migracija • phosphatidylinositol phosphate biosynthetic process • GO:0048554 positive regulation of catalytic activity • phosphatidylinositol-3-phosphate biosynthetic process • positive regulation of protein kinase B signaling • cholesterol homeostasis • Angiogeneza • negative regulation of signal transduction • Ćelijska diferencijacija • negative regulation of apoptotic process • transmembrane receptor protein tyrosine kinase signaling pathway • nervous system development Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	2264	14186
Ensembl	ENSG00000160867	ENSMUSG00000005320
UniProt	P22455	Q03142
RefSeq (mRNK)	NM_001291980 NM_002011 NM_022963 NM_213647 NM_001354984	NM_008011
RefSeq (bjelančevina)	NP_001278909 NP_002002 NP_075252 NP_998812 NP_001341913	NP_032037
Lokacija (UCSC)	Chr 5: 177.09 – 177.1 Mb	Chr 13: 55.3 – 55.32 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Receptor 4 faktora rasta fibroblasta jest protein/enzim koji je kod ljudi kodiran genom FGFR4 sa hromosoma 5. Označava se i kao CD334 (klaster diferencjjacije 334).

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000160867 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000005320 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.